1 Overall survival |
8 |
2001 |
Hazard Ratio (Fixed, 95% CI) |
0.86 [0.78, 0.95] |
1.1 Substitutive comparisons |
3 |
479 |
Hazard Ratio (Fixed, 95% CI) |
1.05 [0.87, 1.27] |
1.2 Additive comparisons |
4 |
1466 |
Hazard Ratio (Fixed, 95% CI) |
0.80 [0.71, 0.91] |
1.3 Other comparisons |
1 |
56 |
Hazard Ratio (Fixed, 95% CI) |
0.80 [0.46, 1.39] |
2 Tumour response |
9 |
1820 |
Odds Ratio (M‐H, Random, 95% CI) |
1.37 [1.03, 1.83] |
2.1 Substitutive comparison |
4 |
525 |
Odds Ratio (M‐H, Random, 95% CI) |
1.03 [0.71, 1.50] |
2.2 Additive comparison |
4 |
1235 |
Odds Ratio (M‐H, Random, 95% CI) |
1.83 [1.45, 2.32] |
2.3 Other comparisons |
1 |
60 |
Odds Ratio (M‐H, Random, 95% CI) |
0.33 [0.12, 0.96] |
3 Time to progression |
2 |
360 |
Hazard Ratio (Random, 95% CI) |
1.06 [0.85, 1.32] |
4 Progression‐free survival |
5 |
1498 |
Hazard Ratio (Random, 95% CI) |
0.76 [0.63, 0.91] |
4.1 Substitutive comparisons |
1 |
119 |
Hazard Ratio (Random, 95% CI) |
1.15 [0.77, 1.72] |
4.2 Additive comparison (PFS) |
3 |
1323 |
Hazard Ratio (Random, 95% CI) |
0.70 [0.61, 0.81] |
4.3 Other comparisons |
1 |
56 |
Hazard Ratio (Random, 95% CI) |
0.94 [0.55, 1.60] |
5 Treatment‐related death |
7 |
2113 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.10 [0.55, 2.20] |
6 Treatment discontinuation due to toxicity |
5 |
1066 |
Odds Ratio (M‐H, Random, 95% CI) |
0.81 [0.53, 1.25] |