Comparison 7. Chemotherapy with capecitabine versus 5‐FU‐containing regimes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall Survival	5	732	Hazard Ratio (Fixed, 95% CI)	0.94 [0.79, 1.11]
2 Tumour response	4	636	Odds Ratio (M‐H, Random, 95% CI)	0.85 [0.40, 1.79]
3 Time to progression	1		Hazard Ratio (Fixed, 95% CI)	Subtotals only
4 Progression‐free survival	4	647	Hazard Ratio (Random, 95% CI)	0.98 [0.77, 1.23]
5 Treatment‐related death	2	481	Odds Ratio (M‐H, Random, 95% CI)	1.88 [0.23, 15.15]
6 Treatment discontinuation due to toxicity	1		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only