Comparison 10. S‐1 versus 5‐FU‐containing regimes.
Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
---|---|---|---|---|
1 Overall Survival | 4 | 1793 | Hazard Ratio (Fixed, 95% CI) | 0.91 [0.83, 1.00] |
2 Tumour response | 7 | 1753 | Odds Ratio (M‐H, Random, 95% CI) | 1.73 [1.01, 2.94] |
3 Progression‐free survival | 4 | 1942 | Hazard Ratio (Random, 95% CI) | 0.85 [0.70, 1.04] |
4 Time‐to treatment failure | 5 | 1818 | Hazard Ratio (Random, 95% CI) | 0.88 [0.76, 1.01] |
5 Treatment‐related deaths | 4 | 1962 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.56 [0.30, 1.06] |
6 Treatment discontinuation due to toxicity | 3 | 1726 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.85 [0.63, 1.13] |