Comparison 10. S‐1 versus 5‐FU‐containing regimes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall Survival	4	1793	Hazard Ratio (Fixed, 95% CI)	0.91 [0.83, 1.00]
2 Tumour response	7	1753	Odds Ratio (M‐H, Random, 95% CI)	1.73 [1.01, 2.94]
3 Progression‐free survival	4	1942	Hazard Ratio (Random, 95% CI)	0.85 [0.70, 1.04]
4 Time‐to treatment failure	5	1818	Hazard Ratio (Random, 95% CI)	0.88 [0.76, 1.01]
5 Treatment‐related deaths	4	1962	Odds Ratio (M‐H, Fixed, 95% CI)	0.56 [0.30, 1.06]
6 Treatment discontinuation due to toxicity	3	1726	Odds Ratio (M‐H, Fixed, 95% CI)	0.85 [0.63, 1.13]