De Lisi 1986.

Methods	Multicentre RCT 2 arms Quality score: B
Participants	n = 85 Median age: 64 years
Interventions	Arm A: 5‐FU 13.5 mg/kg/day for 5 days, every 5 weeks Arm B: carmustine 50 mg/m² on days 1 and 29; doxorubicine 25 mg/m² on days 1, 8, 15, 29 and 36 and mitomycin C 10 mg/m² on day 15
Outcomes	Overall survival, response rate, haematological toxicity
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated
Allocation concealment (selection bias)	Low risk	Centralised
Incomplete outcome data (attrition bias) efficacy	Low risk	ITT
Incomplete outcome data (attrition bias) safety	Low risk	n = 82
Selective reporting (reporting bias)	Low risk	Only haematological toxicity given (in table format ‐ but nonhaematologic side effects were also mentioned)
Other bias	Unclear risk	N/A
Blinded review of CT/MRI‐scans?	High risk	High risk