De Lisi 1986.
Methods | Multicentre RCT 2 arms Quality score: B | |
Participants | n = 85 Median age: 64 years | |
Interventions | Arm A: 5‐FU 13.5 mg/kg/day for 5 days, every 5 weeks Arm B: carmustine 50 mg/m² on days 1 and 29; doxorubicine 25 mg/m² on days 1, 8, 15, 29 and 36 and mitomycin C 10 mg/m² on day 15 |
|
Outcomes | Overall survival, response rate, haematological toxicity | |
Notes | — | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not stated |
Allocation concealment (selection bias) | Low risk | Centralised |
Incomplete outcome data (attrition bias) efficacy | Low risk | ITT |
Incomplete outcome data (attrition bias) safety | Low risk | n = 82 |
Selective reporting (reporting bias) | Low risk | Only haematological toxicity given (in table format ‐ but nonhaematologic side effects were also mentioned) |
Other bias | Unclear risk | N/A |
Blinded review of CT/MRI‐scans? | High risk | High risk |