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. 2017 Jul 13;2017(7):CD004104. doi: 10.1002/14651858.CD004104.pub4

Comparison 1. NIV vs usual care ‐ Overall.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Mortality 12 854 Risk Ratio (M‐H, Fixed, 95% CI) 0.54 [0.38, 0.76]
2 Need for endotracheal intubation 17 1105 Risk Ratio (M‐H, Fixed, 95% CI) 0.36 [0.28, 0.46]
3 Length of hospital stay (days) 10 888 Mean Difference (IV, Random, 95% CI) ‐3.39 [‐5.93, ‐0.85]
4 Length of ICU stay (days) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5 Symptom scores (higher score means more dyspnoea) 4 484 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.16 [‐0.34, 0.02]
5.1 Borg score 2 82 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.35 [‐0.79, 0.08]
5.2 Visual analogue scale 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.87 [‐1.40, ‐0.34]
5.3 Dyspnoea score at 24 hours 1 342 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.21, 0.21]
6 Treatment intolerance 6 252 Risk Difference (M‐H, Fixed, 95% CI) 0.11 [0.04, 0.17]
7 Complications of treatment 6   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
7.1 NIV related 6 567 Risk Ratio (M‐H, Fixed, 95% CI) 29.60 [9.47, 92.51]
7.2 Non‐NIV related 2 125 Risk Ratio (M‐H, Fixed, 95% CI) 0.26 [0.13, 0.53]
8 pH 1 hour post intervention 8 585 Mean Difference (IV, Random, 95% CI) 0.05 [0.02, 0.07]
9 PaCO2 mmHg ‐ 1 hour post intervention 8 585 Mean Difference (IV, Random, 95% CI) ‐4.62 [‐11.05, 1.80]
10 PaO2 mmHg ‐ 1 hour post intervention 8 585 Mean Difference (IV, Random, 95% CI) 7.47 [0.78, 14.16]