Skip to main content
. 2019 Apr 25;2019(4):CD012663. doi: 10.1002/14651858.CD012663.pub2

2. Study characteristics of the diagnostic test accuracy analyses studies.

Study MRI Index biopsy Reference standard Target
 conditions
Study Consecutive
 enrolment
 (study designa) N of
 participants Index
 test(s) MRI‐scale;
 threshold MRI‐TBx
 Technique/route Technique Median N
 cores (range) Independence ISUP
 grade
 (G)
Abd‐Alazeez 2014 No
 (retrospective) 54 MRI 1‐5; ≥ 3 Cognitive/transperineal TTMB 45 (21‐137) No G = 1
 G ≥ 2
 G ≥ 3
Ahmed 2017 Yes
 (prospective) 576 MRI, SBx 1‐5; ≥ 3 NA/transrectal TTMB > 40b Yes G = 1
 G ≥ 2
 G ≥ 3
Dal Moro 2019 Yes
 (prospective) 123 MRI,
 MRI‐TBx,
 MRI‐pathway 1‐5; ≥ 3 Cognitive/transrectal TSBc 24d Yes G = 1
 G ≥ 2
 G ≥ 3
Distler 2017 Yes
 (prospective) Bx‐naïve: 597
 Prior‐negative Bx: 443 MRI,
 MRI‐TBx,
 MRI‐pathway 1‐5; ≥ 3 Software/transperineal TSBe 24 (22‐25) No G ≥ 2
Grey 2015 Yes
 (prospective) Bx‐naïve: 83
 Prior‐negative Bx: 103 MRI 1‐5; ≥ 3 Cognitive/transperineal TSBe (24‐40) No G = 1
 G ≥ 2
 G ≥ 3
Hansen 2016a Yes
 (prospective) 295 MRI,
 MRI‐TBx,
 MRI‐pathway 1‐5; ≥ 3 Software/transperineal TSBe (18‐24) Unclear G = 1
 G ≥ 2
 G ≥ 3
Hansen 2018 Yes
 (prospective) Centre 1: 163
 Centre 3: 242 MRI 1‐5; ≥ 3 Software,
 cognitive/transperineal TSBe 24 (22‐26f),
 20 (20‐21f) No G = 1
 G ≥ 2
 G ≥ 3
Hansen 2017 Unclear
 (prospective) 287 MRI,
 MRI‐TBx,
 MRI‐pathway 1‐5; ≥ 3 Software/transperineal TSBe 24 (24‐25) Unclear G ≥ 2
Kesch 2017 Unclear
 (prospective) Bx‐naïve: 95
 Prior‐negative Bx: 51 MRI,
 MRI‐TBx,
 MRI‐pathway 1‐5; ≥ 3 Software/transperineal TSBg 24 (23‐27f) Yes G = 1
 G ≥ 2
 G ≥ 3
Lawrence 2014 No
 (retrospective) 39 MRI,
 MRI‐TBx,
 MRI‐pathway 1‐4; ≥2 Software/transperineal TSBe 24 (14‐34) No G = 1
 G ≥ 2
Mortezavi 2018 Yes
 (retrospective) 163
 86 MRI,
 MRI‐TBx,
 MRI‐pathway 1‐5; ≥ 3 Software/Transrectal TSB 40 (30‐55) No G = 1
 G ≥ 2
 G ≥ 3
Muthuveloe 2016 Unclear
 (retrospective) 9
 162 MRI 1‐5; ≥ 3 NA TSBh 24 (24–28) Unclear G = 1
 G ≥ 2
 G ≥ 3
Pepe 2013 Unclear
 (prospective) 78 MRI,
 MRI‐TBx,
 MRI‐pathway 0‐1: ≥1 Cognitive/transrectal TSBh 28 (26‐32) No G = 1
 G ≥ 2
Thompson 2016 Yes
 (prospective) 344 MRI 1‐5; ≥ 3 Software,
 cognitive/transperineal TTMB 30 No G = 1
 G ≥ 2
 G ≥ 3
Tsivian 2017 Unclear
 (retrospective) 33 MRI 1‐5; ≥ 3 NA TTMB 55 (42‐63f) Yes G = 1
 G ≥ 2
 G ≥ 3
Nafie 2014 Unclear
 (prospective) 50 SBx NA NA/transrectal TSBh 36 Yes G = 1
 G ≥ 2
 G ≥ 3
Nafie 2017 Unclear
 (prospective) 42 SBx NA NA/transrectal TSBh 36 Yes G = 1
 G ≥ 2
Ploussard 2014 Yes
 (prospective) 2753 SBx NA NA/transrectal TSBc 21 No G = 1
 G ≥ 2
Bx: biopsy; ISUP G : International Society of Urological Pathology grade; MRI: magnetic resonance imaging; MRI‐pathway: magnetic resonance imaging with or without magnetic resonance imaging‐targeted biopsy; MRI‐TBx: magnetic resonance imaging‐targeted biopsy; N: number; NA: not applicable; PI‐RADS v1, v2: Prostate Imaging Reporting Data System version 1 or 2; SBx: systematic biopsy; TSB: transperineal saturation biopsy; TTMB: transperineal template mapping biopsy

aIncluded participants were part of the same study cohort (no randomised populations were included).
 bNot reported but estimated.
 cTransrectal.
 dMean value (as opposed to median).
 eGinsburg biopsies.
 fInterquartile range (as opposed to range).
 gTransperineal optimised prostate biopsy (TOP).
 hIn‐house transperineal saturation biopsy