7. Predictive values of the index tests and prevalences.
Predictive values of the index tests and prostate cancer prevalences | ||||||
Test | MRI populationa | Target condition | N participants (studies) | Prevalenceb (95% CI) | NPVc (95% CI) | PPVc (95% CI) |
MRI | Positive + negative | G = 1 | 1764 (10) | 0.20 (0.17 to 0.23) | 0.79 (0.74 to 0.82) | 0.20 (0.18 to 0.21) |
G ≥ 2 | 3091 (12) | 0.29 (0.22 to 0.38) | 0.91 (0.86 to 0.94) | 0.37 (0.35 to 0.39) | ||
G ≥ 3 | 1438 (7) | 0.14 (0.08 to 0.23) | 0.98 (0.95 to 0.99) | 0.19 (0.17 to 0.21) | ||
MRI‐TBx | Positive | G = 1 | 497 (5) | 0.22 (0.19 to 0.26) | 0.88 (0.78 to 0.94) | 0.98 (0.23 to 1.00) |
G ≥ 2 | 1553 (8) | 0.34 (0.24 to 0.46) | 0.90 (0.85 to 0.93) | 0.88 (0.80 to 0.92) | ||
G ≥ 3 | 428 (3) | 0.21 (0.12 to 0.35) | ID | ID | ||
MRI‐pathway | Positive + negative | G = 1 | 681 (5) | 0.21 (0.18 to 0.24) | 0.85 (0.81 to 0.88) | 0.95 (0.38 to 1.00) |
G ≥ 2 | 2257 (8) | 0.26 (0.18 to 0.36) | 0.91 (0.87 to 0.94) | 0.88 (0.80 to 0.92) | ||
G ≥ 3 | 604 (3) | 0.16 (0.09 to 0.27) | ID | ID | ||
SBx | NA | G = 1 | 3421 (4) | 0.20 (0.16 to 0.25) | 0.90 (0.81 to 0.95) | 0.94 (0.37 to 1.00) |
G ≥ 2 | 3421 (4) | 0.34 (0.21 to 0.51) | 0.84 (0.60 to 0.95) | 1.00 (0.76 to 1.00) | ||
G ≥ 3 | 626 (2) | 0.10 (0.08 to 0.12) | ID | ID | ||
CI: confidence interval; G: International Society of Urological Pathology grade; ID: inadequate data; MRI: magnetic resonance imaging; MRI‐pathway: magnetic resonance imaging with or without magnetic resonance imaging‐targeted biopsy; MRI‐TBx: magnetic resonance imaging‐targeted biopsy; NA: not applicable; NPV: negative predictive value; PPV: positive predictive value; SBx: systematic biopsy |
aData did not allow differentiation between the mix of included participants (biopsy‐naïve and prior‐negative biopsy men). bPrevalence is pooled estimate of all detected cancer by template‐guided biopsy. cBased on the Bayes’ theorem using the point estimates and 95% confidence intervals of the pooled positive and negative likelihood ratio and the point estimate of the prevalence.