8. MRI‐positivity threshold effect.
MRI‐positivity threshold effect, verified by template‐guided biopsy as the reference standard, with threshold ≥ 3and ≥ 4 out of 5 for identifying prostate cancer | |||||
MRI threshold | Target condition | N participants (studies)a | Proportion negative MRI (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
≥ 3/5 | G = 1 | 1647 (8) | 0.29 (0.21 to 0.40) | 0.68 (0.57 to 0.77) | 0.28 (0.19 to 0.39) |
G ≥ 2 | 2974 (10) | 0.30 (0.23 to 0.38) | 0.89 (0.82 to 0.94) | 0.39 (0.32 to 0.47) | |
G ≥ 3 | 1438 (7) | 0.31 (0.21 to 0.42) | 0.96 (0.87 to 0.99) | 0.35 (0.26 to 0.46) | |
≥ 4/5 | G = 1 | 834 (4) | 0.60 (0.38 to 0.78) | 0.26 (0.16 to 0.40) | 0.57 (0.36 to 0.76) |
G ≥ 2 | 1083 (5) | 0.59 (0.43 to 0.74) | 0.72 (0.52 to 0.86) | 0.78 (0.68 to 0.86) | |
G ≥ 3 | 834 (4) | 0.60 (0.38 to 0.78) | 0.86 (0.51 to 0.97) | 0.68 (0.51 to 0.81) | |
CI: confidence interval; G: International Society of Urological Pathology grade; MRI: magnetic resonance imaging; N: number |
aData did not allow differentiation between the mix of included participants (biopsy‐naïve and prior‐negative biopsy men).