8. MRI‐positivity threshold effect.

MRI‐positivity threshold effect, verified by template‐guided biopsy as the reference standard, with threshold ≥ 3and ≥ 4 out of 5 for identifying prostate cancer
MRI threshold	Target condition	N participants (studies)a	Proportion negative MRI (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)
≥ 3/5	G = 1	1647 (8)	0.29 (0.21 to 0.40)	0.68 (0.57 to 0.77)	0.28 (0.19 to 0.39)
	G ≥ 2	2974 (10)	0.30 (0.23 to 0.38)	0.89 (0.82 to 0.94)	0.39 (0.32 to 0.47)
	G ≥ 3	1438 (7)	0.31 (0.21 to 0.42)	0.96 (0.87 to 0.99)	0.35 (0.26 to 0.46)
≥ 4/5	G = 1	834 (4)	0.60 (0.38 to 0.78)	0.26 (0.16 to 0.40)	0.57 (0.36 to 0.76)
	G ≥ 2	1083 (5)	0.59 (0.43 to 0.74)	0.72 (0.52 to 0.86)	0.78 (0.68 to 0.86)
	G ≥ 3	834 (4)	0.60 (0.38 to 0.78)	0.86 (0.51 to 0.97)	0.68 (0.51 to 0.81)
CI: confidence interval; G: International Society of Urological Pathology grade; MRI: magnetic resonance imaging; N: number

^aData did not allow differentiation between the mix of included participants (biopsy‐naïve and prior‐negative biopsy men).