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. 2018 Jun 20;45(3):698–708. doi: 10.1093/schbul/sby085

Fig. 4.

Fig. 4.

Expression and functional characterization of schizophrenia candidate genes (SZgenes). (A) Density plot of 2-stage gene expression pattern for SZgenes using the BrainSpan dataset. β value (x-axis) was obtained by comparison of expression before and after birth. A positive β value indicates the gene has higher expression after birth than before birth. One-sided t test was performed for genes with positive β values and genes with negative β values. (B) Six classes of expression patterns (I–VI) of SZgenes. x-axis: developmental stages: before birth (b.b), infancy (age ≤ 2), and childhood to adulthood (age > 2). y-axis: expression intensity. The top panel showed the expression pattern using the BrainSpan data (RNA-sequencing), with each line indicating 1 gene. The bottom panel showed the expression pattern using the BrainCloud data (microarray data), with each line indicating 1 probe. In the bottom panel, #genes (A) indicates the number of genes from the corresponding cluster in the BrainSpan data (top panel) that were also available in the BrainCloud data, and #genes (M) indicates the number of genes showing the matched expression pattern in the BrainCloud data (highlighted as red lines). (C) Example genes for each class using the BrainSpan data. Each dot represents a gene in a sample; dot color indicates stages. (D) Functional gene set enrichment analysis. PSD: postsynaptic densities. NRC: N-methyl-d-aspartate receptor complex. PSP: postsynaptic proteome. Details of the gene sets are provided in table S3. Only gene sets with significant enrichment in any of the 9 SZgene sets (P < .05, Bonferroni method) were shown.