Table 1.
SZgenes Interact With Each Other More Often Than by Chance
| Reference network | Total | S1 | S2 | S3 | S4 | S5 | S6 | S7 | S8 | S9 |
|---|---|---|---|---|---|---|---|---|---|---|
| STRING and HPRD |
V = 10 349 E = 52 663 |
V = 133 E = 9 P = .3488 |
V = 209 E = 38 P = .0253 |
V = 229 E = 57 P = .0053 |
V = 280 E = 115 P < 1 × 10−4 |
V = 329 E = 127 P = 2 × 10−4 |
V = 375 E = 167 P < 1 × 10−4 |
V = 380 E = 171 P = 1 × 10−4 |
V = 380 E = 171 P < 1 × 10−4 |
V = 381 E = 172 P = 1 × 10−4 |
| Pathway Common |
V = 16 305 E = 369 884 |
V = 180 E = 113 P = .0028 |
V = 276 E = 325 P < 1 × 10−4 |
V = 301 E = 404 P < 1 × 10−4 |
V = 356 E = 662 P < 1 × 10−4 |
V = 430 E = 835 P < 1 × 10−4 |
V = 500 E = 1081 P < 1 × 10−4 |
V = 506 E = 1101 P < 1 × 10−4 |
V = 506 E = 1101 P < 1 × 10−4 |
V = 507 E = 1103 P < 1 × 10−4 |
| HumanNet bench |
V = 5236 E = 269 410 |
V = 75 E = 74 P = .0973 |
V = 114 E = 211 P = .0037 |
V = 126 E = 237 P = .0099 |
V = 163 E = 419 P = .0015 |
V = 188 E = 549 P = .0011 |
V = 209 E = 739 P = 1 × 10−4 |
V = 212 E = 739 P = 2 × 10−4 |
V = 212 E = 739 P < 1 × 10−4 |
V = 212 E = 739 P = 1 × 10−4 |
| HumanNet joint |
V = 16 117 E = 474 714 |
V = 185 E = 108 P = .0084 |
V = 280 E = 272 P = 3 × 10−4 |
V = 305 E = 357 P < 1 × 10−4 |
V = 360 E = 561 P < 1 × 10−4 |
V = 431 E = 726 P < 1 × 10−4 |
V = 500 E = 1003 P < 1 × 10−4 |
V = 506 E = 1025 P < 1 × 10−4 |
V = 506 E = 1025 P < 1 × 10−4 |
V = 506 E = 1025 P < 1 × 10−4 |
SZgenes = schizophrenia candidate genes.
S1–S9 represents the SZgene sets. V: number of nodes. E: number of edges. P values were obtained through 10 000 randomization sets selected from the background network with the same number of each SZgenes set (S1–S9).