Table 3.

Results of Meta-analysis of Resting-State Functional Connectivity in FEP, After Sensitivity Analysis

Seed Network and Anatomy	Direction of Difference in FC	Effect Anatomy	Coordinates (MNI)			SDM-Z	P-value	SDM-Estimate	No. of Voxels	Jack-Knife Survival Rate	Egger Test, P-value
			x	y	z
DMN: dMPFC, PCC, TPJ, hippocampus, MPFC, MTG, v. precuneus	FEP > HC	Inf. semi-lunar cerebellar lobule	36	−68	−48	1.304	.00033	0.093	1118	10/11	.394
	FEP < HC	Medial orbital gyrus	−12	36	−22	−1.59	.00048	−0.11	353	10/11	.841
		Cerebellum	−40	−54	−58	−1.303	.0026	−0.093	145	10/11	.348
		(Ventral anterior) cingulate gyrus	6	14	−4	−1.526	.00077	−0.11	131	10/11	.953
		Inferior frontal gyrus	−48	44	−2	−1.303	.0027	−0.093	99	10/11	.377
		Superior temporal gyrus	−48	16	−16	−1.304	.0026	−0.093	64	10/11	.377
		(Dorsal anterior) cingulate gyrus	10	46	8	−1.391	.0018	−0.099	40	10/11	.451
SN: amygdala, DC, sVC, iVC, dACC, insula, OFC	FEP > HC	Occipital gyrus	−18	−94	28	293	.0004	1.205	293	10/12	.448
		Superior temporal gyrus	64	−38	20	128	.00038	1.205	128	11/12	.449
		Post. transverse temporal gyrus	54	−30	20	126	.00068	1.187	126	10/12	.452
		Superior frontal gyrus	26	0	66	38	.00054	1.196	38	11/12	.447
	FEP < HC	Middle temporal gyrus	48	6	−16	−1.92	.000015	−0.223	1752	12/12	.304
		Middle temporal gyrus	−60	−38	−6	−1.837	.000034	−0.174	1294	12/12	.084
		Planum polare	−46	6	−8	−1.233	.0029	−0.095	85	10/12	.499
		Cerebellum/culmen	4	−58	−22	−1.205	.0033	−0.093	85	11/12	.449
		Middle frontal gyrus	26	66	10	−1.402	.0011	−0.151	82	10/12	.141
		Superior frontal gyrus	−22	52	36	−1.248	.0027	−0.107	23	10/12	.167

Note: Results of comparison between individuals with first-episode psychosis (FEP) and healthy controls (HC), after jack-knife sensitivity analysis. Results were thresholded at P < .005 uncorrected (equivalent to P < .05 corrected), peak threshold of 1, extent threshold of 10. Seed networks included default mode network (DMN), and salience network (SN). dMPFC, dorsomedial prefrontal cortex; PCC, posterior cingulate cortex; TPJ, temporoparietal junction; MPFC, medial prefrontal cortex; dACC, dorsal anterior cingulate cortex; MTG, medial temporal gyrus; v. precuneus, ventral precuneus; DC, dorsal caudate; sVC, superior ventral caudate; iVC, inferior ventral caudate; OFC, orbitofrontal cortex; SDM-Z, SDM test statistic. SDM-estimate, effect size created by SDM. Coordinates are MNI standard stereotaxic space. Voxels = number of 1 mm × 1 mm × 1 mm voxels. Jack-knife survival rate refers to number of iterations the peak survived out of the total number of iterations, during the jack-knife sensitivity analyses.