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. 2019 Mar 7;4(5):e123130. doi: 10.1172/jci.insight.123130

Figure 5. Canagliflozin triggers coordinated interorgan nutrient repartitioning from adipose tissue.

Figure 5

(A) Tissue weight after 9 weeks of CANA (n = 12/group). gWAT, perigonadal; SC, subcutaneous; BAT, brown adipose tissue. (B) Representative H&E-stained subcutaneous adipose section. Original magnification, ×40. (C) Quantification of adipocyte size (n = 8/group). (D) Percentage change in free fatty acids after CL-316243 injection (0.1 mg/kg, n = 6/group). (E) qPCR analysis of subcutaneous adipose gene expression after 4 hour fast (n = 6/group). P values (1-way ANOVA). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.