Extensive tests versus tests at the physician's discretion
Patient or population: people with unprovoked VTE Setting: hospital Intervention: extensive tests Comparison: tests at physician's discretion
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	No of participants (studies)	Quality of the evidence (GRADE)	Comments
	Risk with tests at physician's discretion	Risk with extensive tests
Characteristics of diagnosed cancer: type of cancer ‐ lung	Study population		OR 2.08 (0.19 to 23.34)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	10 per 1000	20 per 1000 (2 to 188)
Characteristics of diagnosed cancer: type of cancer ‐ bladder	Study population		OR 2.08 (0.19 to 23.34)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	10 per 1000	20 per 1000 (2 to 188)
Characteristics of diagnosed cancer: type of cancer ‐ stomach	Study population		OR 1.03 (0.06 to 16.71)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	10 per 1000	10 per 1000 (1 to 142)
Characteristics of diagnosed cancer: type of cancer ‐ kidney	Study population		OR 3.12 (0.13 to 77.55)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	0 per 1000	0 per 1000 (0 to 0)
Characteristics of diagnosed cancer: type of cancer ‐ adrenal gland	Study population		OR 3.12 (0.13 to 77.55)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	0 per 1000	0 per 1000 (0 to 0)
Characteristics of diagnosed cancer: type of cancer ‐ liver	Study population		OR 3.12 (0.13 to 77.55)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	0 per 1000	0 per 1000 (0 to 0)
Characteristics of diagnosed cancer: type of cancer ‐ uterus	Study population		OR 3.12 (0.13 to 77.55)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	0 per 1000	0 per 1000 (0 to 0)
Characteristics of diagnosed cancer: type of cancer ‐ breast	Study population		OR 1.03 (0.06 to 16.71)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	10 per 1000	10 per 1000 (1 to 142)
Characteristics of diagnosed cancer: type of cancer ‐ ovary	Study population		OR 3.12 (0.13 to 77.55)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	0 per 1000	0 per 1000 (0 to 0)
Characteristics of diagnosed cancer: type of cancer ‐ colon	Study population		OR 0.51 (0.05 to 5.72)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	20 per 1000	10 per 1000 (1 to 103)
Characteristics of diagnosed cancer: type of cancer ‐ prostate	Study population		OR 0.51 (0.05 to 5.72)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	20 per 1000	10 per 1000 (1 to 103)
Characteristics of diagnosed cancer: type of cancer ‐ pancreas	Study population		OR 0.20 (0.01 to 4.26)	201 (1 RCT)	⊕⊕⊝⊝ Low1	‐
	20 per 1000	4 per 1000 (0 to 79)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio; RCT: randomised controlled trial; VTE: venous thromboembolism.
GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.