3. Orphan outcomes.
| Study | Outcome | Participants | Results |
| Base 2011 | Respiratory failure | 81 | Four participants (9.3%) in buffered group and 1 (2.6%) in non‐buffered group developed respiratory failure. |
| Gan 1999 | Need for intraoperative calcium | 120 | Mean intraoperative calcium given was 4.2 mg in the buffered group and 220 mg in the non‐buffered group (P < 0.05). |
| Gan 1999 | Prothrombin time | 120 | Prothrombin time for buffered group was 16 seconds (± 4) and for non‐buffered group was 17 seconds (± 7). No important differences between groups |
| Khajavi 2008 | Renal artery thrombosis | 52 | 2 participants in buffered fluids group (lactated Ringer's) developed renal artery thrombosis and subsequent graft failure. No similar incidences were recorded in the non‐buffered fluids group (normal saline). No important differences between groups |
| Kulla 2008 | Blood loss on first postop day | 61 | Blood loss on first postoperative day in the buffered group was 289 ± 325 mL and in the non‐buffered group was 309 ± 250 mL. No important differences between groups |
| Kulla 2008 | Factor VIII at 6 hours postop and on first postop day | 61 | Factor VIII levels at 6 hours postop was 141% ± 49 and 142% ± 49 for buffered and non‐buffered groups, respectively. No statistically significant differences Factor VIII levels first postoperative day was 123% ± 47 and 132% ± 43 for buffered and non‐buffered groups, respectively. No important differences between groups |
| Kulla 2008 | Ristocetin cofactor at 6 hours postop and on first postop day | 61 | Ristocetin cofactor levels at 6 hours postop were 143% ± 15 and 148% ± 10 for buffered and non‐buffered groups, respectively. No statistically significant differences Ristocetin cofactor levels on first postop day were 145% ± 14 and 150% ± 0 for buffered and non‐buffered groups, respectively. No important differences between groups |
| Moretti 2003 | Postop nausea | 60 | Postoperative nausea was reported in 22 (73%) participants in the buffered group and in 14 (47%) participants in the non‐buffered group. |
| O'Malley 2005 | Serum creatinine 6 months postop | 51 | Serum creatinine at 6 months was 133 ± 54 μmol/L and 133 ± 35 μmol/L for buffered and non‐buffered groups, respectively. |
| Song 2015 | Rotational Thromboelastography | 50 | ROTEM analyses revealed that values of MCF in FibTEM, CFT, a angle and MCF in INTEM, CT, CFT, a angle and MCF in EXTEM at end of surgery were changed towards a hypocoagulable state compared with their corresponding baseline values in both groups (P < 0.05). However, no important differences in FibTEM, INTEM, and EXTEM analyses were noted between Plasmalyte and NS groups. |
| Takil 2002 | Serum bicarbonate at 5 to 10 hours postop | 30 | Serum bicarbonate at 6 hours was 23.6 ± 2.2 mmol/L and 19.3 ± 2.2 mmol/L for buffered and non‐buffered groups, respectively (P < 0.01). |
| Wilkes 2001 | Gastric tonometry | 47 | Gastric tonometry showed P(g‐a)CO2 of 0.9 ± 1.1 kPa in the balanced group and 1.7 ± 0.5 kPa in the unbalanced group (P = 0.04). |
| Wilkes 2001 | Serum total calcium | 47 | Postoperative total serum calcium was 2.0 ± 0.2 mmol/L for the balanced group and 1.6 ± 0.2 mmol/L for the non‐balanced group (P = 0.0001). |
Data potentially of interest to this review but reported only in single studies and therefore not suitable for numerical analysis.
CFT: clot formation time; CT: clotting time; EXTEM, FibTEM, INTEM: Trade names for types of ROTEM assay; kPa: kilopascals; MCF: maximum clot firmness; mL: millilitres; mmol/L: millimols per litre; NS: normal saline; P(g‐a)CO2: partial pressure of gastric minus arterial carbon dioxide; postop: postoperative; ROTEM: manufacturer's name of device ‐ Rotational Thromboelastometry; s: seconds;:μmol/L: micromols/litre.