Comparison 2.
Levonorgestrel versus Yuzpe
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Observed number of pregnancies (all women) | 6 | 4750 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.57 [0.39, 0.84] |
| 2 Observed number of pregnancies (by risk status) | 2 | 2781 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.50 [0.31, 0.82] |
| 2.1 High‐risk women | 2 | 888 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.39 [0.19, 0.80] |
| 2.2 Low‐risk women | 2 | 1893 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.64 [0.32, 1.26] |
| 3 Observed number of pregnancies (time from intercourse) | 2 | 2632 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.48 [0.28, 0.82] |
| 3.1 Within 24 h | 2 | 1343 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.51 [0.19, 1.34] |
| 3.2 25‐48 h | 2 | 952 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.42 [0.19, 0.94] |
| 3.3 49‐72 h | 1 | 337 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.57 [0.19, 1.77] |
| 4 Need for extra dose | 1 | 1955 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.53 [0.38, 0.75] |
| 5 Any side effect | 1 | 1955 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.80 [0.75, 0.86] |
| 6 Specific side effects | 6 | Risk Ratio (M‐H, Fixed, 95% CI) | Subtotals only | |
| 6.1 Nausea | 6 | 4750 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.40 [0.36, 0.44] |
| 6.2 Vomiting | 5 | 3640 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.29 [0.24, 0.35] |
| 6.3 Headache | 3 | 2606 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.82 [0.71, 0.94] |
| 6.4 Dizziness | 3 | 3318 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.74 [0.65, 0.85] |
| 6.5 Fatigue | 6 | 4750 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.67 [0.60, 0.74] |
| 6.6 Breast tenderness | 3 | 3318 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.76, 1.06] |
| 6.7 Diarrhoea | 1 | 529 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.94 [0.66, 1.32] |
| 6.8 Spotting/bleeding after treatment | 2 | 1614 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.82 [1.37, 2.41] |
| 6.9 Abdominal pain | 1 | 1955 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.84 [0.70, 1.01] |
| 6.10 Hot flushes | 1 | 122 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.48 [0.09, 2.54] |
| 6.11 Stomach pain | 1 | 529 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.00 [0.81, 1.24] |
| 6.12 Nose spot | 1 | 529 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.10 [0.80, 1.52] |
| 7 Menses | 3 | 3298 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.19 [0.99, 1.44] |
| 7.1 Early | 2 | 1310 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.15 [0.86, 1.52] |
| 7.2 Delay | 3 | 1988 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.23 [0.96, 1.57] |