Comparison 5.
Mifepristone low dose (< 25 mg) versus levonorgestrel 1.5 mg
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Observed number of pregnancies (all women) | 14 | 8752 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.72 [0.52, 0.99] |
| 2 Observed number of pregnancies (by risk status) | 1 | 4071 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.92 [0.55, 1.55] |
| 2.1 High‐risk women | 1 | 1235 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.32 [0.67, 2.60] |
| 2.2 Low‐risk women | 1 | 2836 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.59 [0.25, 1.35] |
| 3 Observed number of pregnancies (time from intercourse) | 2 | 6074 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.85 [0.56, 1.28] |
| 3.1 Within 72 h | 2 | 5553 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.82 [0.53, 1.27] |
| 3.2 Later than 72 h | 2 | 521 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.11 [0.35, 3.57] |
| 4 Any side effect | 3 | 609 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.26 [0.17, 0.38] |
| 5 Specific side effect | 8 | Risk Ratio (M‐H, Random, 95% CI) | Subtotals only | |
| 5.1 Nausea | 5 | 6384 | Risk Ratio (M‐H, Random, 95% CI) | 0.95 [0.84, 1.09] |
| 5.2 Vomiting | 3 | 6085 | Risk Ratio (M‐H, Random, 95% CI) | 1.22 [0.55, 2.68] |
| 5.3 Headache | 3 | 6082 | Risk Ratio (M‐H, Random, 95% CI) | 1.06 [0.83, 1.37] |
| 5.4 Dizziness | 4 | 6181 | Risk Ratio (M‐H, Random, 95% CI) | 0.92 [0.79, 1.08] |
| 5.5 Fatigue | 3 | 6077 | Risk Ratio (M‐H, Random, 95% CI) | 1.06 [0.94, 1.21] |
| 5.6 Breast tenderness | 3 | 6084 | Risk Ratio (M‐H, Random, 95% CI) | 1.03 [0.88, 1.21] |
| 5.7 Diarrhoea | 2 | 4184 | Risk Ratio (M‐H, Random, 95% CI) | 1.26 [0.93, 1.73] |
| 5.8 Spotting/bleeding after treatment | 5 | 4598 | Risk Ratio (M‐H, Random, 95% CI) | 0.61 [0.54, 0.69] |
| 5.9 Low abdominal pain | 4 | 5105 | Risk Ratio (M‐H, Random, 95% CI) | 0.94 [0.83, 1.06] |
| 5.10 Hot flushes | 1 | 723 | Risk Ratio (M‐H, Random, 95% CI) | 0.93 [0.65, 1.33] |
| 6 Menses | 9 | Risk Ratio (M‐H, Fixed, 95% CI) | Subtotals only | |
| 6.1 Early | 5 | 1800 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.45 [0.35, 0.59] |
| 6.2 Delay | 9 | 7520 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.70 [1.48, 1.97] |
| 7 ITT (all loss follow‐up as pregnancy in LNG, and no preg in Mifepristone) | 9 | 8429 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.70 [0.50, 0.98] |
| 8 ITT (all loss follow‐up as no pregnancy in LNG, and preg in Mifepristone) | 9 | 8429 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.76, 1.05] |