Comparison 23.

Mid dose mifepristone split dose comparisons

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Observed number of pregnancies (all women)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 25 mg 12‐hrly x 2 versus 10 mg daily x 3 days	1	236	Risk Ratio (M‐H, Fixed, 95% CI)	1.93 [0.18, 21.03]
1.2 25 mg 12‐hrly x 2 versus 10 mg daily x 5 days	1	238	Risk Ratio (M‐H, Fixed, 95% CI)	4.92 [0.24, 101.35]
1.3 10 mg daily x 3 days versus 10 mg daily x 5 days	1	234	Risk Ratio (M‐H, Fixed, 95% CI)	3.05 [0.13, 74.14]
2 Any side effect	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 25 mg 12‐hrly x 2 versus 10 mg daily x 3 days	1	236	Risk Ratio (M‐H, Fixed, 95% CI)	28.04 [1.69, 464.70]
2.2 25 mg 12‐hrly x 2 versus 10 mg daily x 5 days	1	238	Risk Ratio (M‐H, Fixed, 95% CI)	28.52 [1.72, 472.69]
2.3 10 mg daily x 3 days versus 10 mg daily x 5 days	1	234	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Early menses	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 25 mg 12‐hrly x 2 versus 10 mg daily x 3 days	1	236	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.63, 1.77]
3.2 25 mg 12‐hrly x 2 versus 10 mg daily x 5 days	1	238	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.64, 1.80]
3.3 10 mg daily x 3 days versus 10 mg daily x 5 days	1	234	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.60, 1.73]
4 Delay menses	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 25 mg 12‐hrly x 2 versus 10 mg daily x 3 days	1	236	Risk Ratio (M‐H, Fixed, 95% CI)	1.86 [1.03, 3.37]
4.2 25 mg 12‐hrly x 2 versus 10 mg daily x 5 days	1	238	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.70, 1.89]
4.3 10 mg daily x 3 days versus 10 mg daily x 5 days	1	234	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.34, 1.14]