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. 2017 Aug 2;2017(8):CD001324. doi: 10.1002/14651858.CD001324.pub5

Comparison 24.

Mifepristone high dose (> 50 mg) versus mifepristone low dose (< 25 mg)

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Observed number of pregnancies (all women) 5 1726 Risk Ratio (M‐H, Fixed, 95% CI) 0.52 [0.23, 1.17]
2 Observed number of pregnancies (by risk status) 1 1102 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.29, 3.41]
2.1 High‐risk women 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2.2 Low‐risk women 1 1102 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.29, 3.41]
3 Any side effect 3 512 Risk Ratio (M‐H, Fixed, 95% CI) 13.04 [5.13, 33.15]
4 Specific side effects 3 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Nausea 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 1.67 [0.42, 6.56]
4.2 Vomiting 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.3 Headache 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.4 Dizziness 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 1.5 [0.26, 8.55]
4.5 Fatigue 2 1210 Risk Ratio (M‐H, Fixed, 95% CI) 1.25 [1.00, 1.56]
4.6 Breast tenderness 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 5.0 [0.25, 101.31]
4.7 Diarrhoea 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 1.5 [0.26, 8.55]
4.8 Spotting/bleeding after treatment 2 1224 Risk Ratio (M‐H, Fixed, 95% CI) 2.36 [1.89, 2.95]
4.9 Abdominal pain 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Menses 4 Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Early 0 0 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5.2 Delay 4 1574 Risk Ratio (M‐H, Fixed, 95% CI) 1.98 [1.66, 2.37]