Methods |
Women randomly allocated to 2 groups. Method of randomisation not reported |
Participants |
200 women attending in a family planning clinic, Tongxiang, Zhejiang, China. Women had regular menstrual periods and a single act of unprotected intercourse within 72 h of attending the clinic |
Interventions |
LNG‐COC, 4 tablets (total ethinyl oestradiol 0.12 mg and LNG 0.6 mg) 2‐dose, 12 h apart, orally vs LNG 0.75 mg, 2‐dose, 12 h apart, orally |
Outcomes |
Observed number of pregnancies, side effects and changes in menstrual pattern |
Notes |
Observed pregnancy/total number of women: LNG‐COC: 1/100; LNG: 1/100
-
Side effects:
LNG‐COC: nausea 33/100; vomiting 5/100; dizziness and fatigue 12/100
LNG: nausea 15/100; vomiting 3/100; dizziness and fatigue 9/100
-
Changes in menstrual pattern:
Early: LNG‐COC 10/100; LNG 14/100
Delay: LNG‐COC 8/100; LNG 10/100
|
Risk of bias |
Bias |
Authors' judgement |
Support for judgement |
Random sequence generation (selection bias) |
Unclear risk |
Mentioned randomisation but description not adequate |
Allocation concealment (selection bias) |
Unclear risk |
Method of allocation concealment not mentioned |
Blinding (performance bias and detection bias) All outcomes |
Unclear risk |
Not mentioned |
Incomplete outcome data (attrition bias) All outcomes |
Unclear risk |
No mention of post‐randomisation exclusion and loss to follow‐up |
Selective reporting (reporting bias) |
Low risk |
Reported planned outcomes |
Other bias |
Low risk |
None detected |