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. 2019 Apr 4;4(7):e125107. doi: 10.1172/jci.insight.125107

Figure 2. STING ligands enhance the functionality of effector CD8+ T cells.

Figure 2

(A) Intracellular expression of perforin and granzyme B among EV10-specific CD8+ T cells primed in the presence of 2′3′-cGAMP or TLR4 and expanded for a further 2 weeks in culture after restimulation with EV10. (B) Intracellular expression of IFN-γ among EV10-specific CD8+ T cells generated as in A after exposure to HLA-A2+ or HLA-A2– melanoma cells (effector/target ratio 1:10). (C) Lysis of HLA-A2+ or HLA-A2– melanoma cells by EV10-specific CD8+ T cells generated as in A. Error bars indicate mean ± SEM (n = 3 replicates). **P < 0.01, ***P < 0.001 (unpaired t test).