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. 2019 Apr 4;4(7):e124620. doi: 10.1172/jci.insight.124620

Figure 4. Dietary unsaturated fat increases the metabolism of HDL containing apoE.

Figure 4

(A and B) HDL containing apoE (E+) has a faster FCR than HDL lacking apoE (E–) on both high-fat and high-carbohydrate diets. (C and D) Dietary unsaturated fat increases the clearance rates of the larger sizes (α-1 and α-2) of E+. ApoA-I fractional catabolic (turnover) rates (FCRs) in pools/day are shown for each HDL subspecies during intake of 2 diets. Each data point is an individual study participant (n = 9 for all). Black bar = mean, error bars = SEM. LFD, low-fat diet; HFD, high-fat diet. P values were calculated using paired 2-tailed t test. Overall P value for comparison considering all sizes together is shown on each graph. (A) Comparison of apoA-I FCRs on subspecies of E+ or E– in the context of a high-fat diet. (B) Comparison of apoA-I FCRs on subspecies of E+ or E– in the context of a low-fat diet. (C) Comparison of apoA-I FCRs across 2 diets only among the subspecies of E+. (D) Comparison of apoA-I FCRs across 2 diets only among the subspecies of E–.