Comparison 3. Active NRT vs placebo ‐ rs16969968 ‐ non‐Hispanic black or African American.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Six‐Month Abstinence	2	709	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.55, 2.26]
1.1 Homozygous Major	2	637	Risk Ratio (M‐H, Random, 95% CI)	1.47 [1.07, 2.03]
1.2 Heterozygous or Homozygous Minor	2	72	Risk Ratio (M‐H, Random, 95% CI)	0.43 [0.15, 1.26]
2 End of Treatment	2	709	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.36, 2.94]
2.1 Homozygous Major	2	637	Risk Ratio (M‐H, Random, 95% CI)	1.57 [1.15, 2.15]
2.2 Heterozygous or Homozygous Minor	2	72	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.10, 0.86]