Comparison 12. Bupropion vs placebo ‐ rs588765 ‐ non‐Hispanic white.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Six‐Month Abstinence	4	1107	Risk Ratio (M‐H, Random, 95% CI)	1.37 [1.12, 1.67]
1.1 Homozygous Major	4	384	Risk Ratio (M‐H, Random, 95% CI)	1.33 [0.85, 2.08]
1.2 Heterozygous	4	526	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.95, 1.65]
1.3 Homozygous Minor	4	197	Risk Ratio (M‐H, Random, 95% CI)	1.95 [1.18, 3.22]
2 End of Treatment	4	1107	Risk Ratio (M‐H, Random, 95% CI)	1.36 [1.13, 1.65]
2.1 Homozygous Major	4	385	Risk Ratio (M‐H, Random, 95% CI)	1.37 [1.05, 1.79]
2.2 Heterozygous	4	525	Risk Ratio (M‐H, Random, 95% CI)	1.31 [0.86, 2.01]
2.3 Homozygous Minor	4	197	Risk Ratio (M‐H, Random, 95% CI)	1.43 [0.99, 2.06]