Comparison 13. Bupropion vs placebo ‐ rs2036527 ‐ non‐Hispanic white.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Six‐Month Abstinence	2	738	Risk Ratio (M‐H, Random, 95% CI)	1.40 [1.05, 1.86]
1.1 Homozygous Major	2	260	Risk Ratio (M‐H, Random, 95% CI)	1.15 [0.73, 1.80]
1.2 Heterozygous	2	370	Risk Ratio (M‐H, Random, 95% CI)	1.43 [0.99, 2.06]
1.3 Homozygous Minor	2	108	Risk Ratio (M‐H, Random, 95% CI)	2.73 [1.02, 7.36]
2 End of Treatment	4	975	Risk Ratio (M‐H, Random, 95% CI)	1.43 [1.19, 1.73]
2.1 Homozygous Major	4	339	Risk Ratio (M‐H, Random, 95% CI)	1.37 [1.04, 1.80]
2.2 Heterozygous	4	482	Risk Ratio (M‐H, Random, 95% CI)	1.36 [1.04, 1.79]
2.3 Homozygous Minor	4	154	Risk Ratio (M‐H, Random, 95% CI)	2.64 [1.33, 5.25]