Comparison 15. Bupropion vs placebo ‐ rs3733829 ‐ non‐Hispanic white.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Six‐Month Abstinence	2	571	Risk Ratio (M‐H, Random, 95% CI)	1.41 [1.07, 1.87]
1.1 Homozygous Major	2	268	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.81, 1.82]
1.2 Heterozygous	2	218	Risk Ratio (M‐H, Random, 95% CI)	1.95 [1.22, 3.13]
1.3 Homozygous Minor	2	85	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.58, 2.17]
2 End of Treatment	4	807	Risk Ratio (M‐H, Random, 95% CI)	1.55 [1.29, 1.87]
2.1 Homozygous Major	4	367	Risk Ratio (M‐H, Random, 95% CI)	1.44 [1.11, 1.86]
2.2 Heterozygous	4	333	Risk Ratio (M‐H, Random, 95% CI)	1.69 [1.24, 2.30]
2.3 Homozygous Minor	4	107	Risk Ratio (M‐H, Random, 95% CI)	1.69 [0.96, 2.95]