Comparison 57. Active NRT ‐ rs1051730 ‐ non‐Hispanic white.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Six‐Month Abstinence	7		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Homozygous Major vs Homozygous Minor	7	1559	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.71, 1.19]
1.2 Heterozygous vs Homozygous Minor	7	1650	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.75, 1.11]
2 End of Treatment	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Homozygous Major vs Homozygous Minor	5	1200	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.73, 1.06]
2.2 Heterozygous vs Homozygous Minor	5	1291	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.79, 1.10]