Comparison 101. Placebo ‐ rs1051730 ‐ non‐Hispanic white.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Six‐Month Abstinence	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Homozygous Major vs Homozygous Minor	6	533	Risk Ratio (M‐H, Random, 95% CI)	1.29 [0.86, 1.92]
1.2 Heterozygous vs Homozygous Minor	6	597	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.72, 1.62]
2 End of Treatment	7		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Homozygous Major vs Homozygous Minor	7	542	Risk Ratio (M‐H, Random, 95% CI)	1.39 [0.91, 2.13]
2.2 Heterozygous vs Homozygous Minor	7	605	Risk Ratio (M‐H, Random, 95% CI)	1.24 [0.81, 1.89]