Suzuki 2015.
Methods | Randomised, double‐blind, placebo‐controlled trial (N = 208) | |
Participants | Patients with moderate‐to‐severely active UC | |
Interventions | Group 1: 5 mg/kg infliximab (n = 104) Group 2: placebo (n = 104) Patients received treatment at weeks 0, 2 and 6 Patients with a lower MCS at week 8 than at baseline were further treated with infliximab at weeks 14 and 22 |
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Outcomes | Primary outcome: clinical response Secondary outcomes: clinical remission, mucosal healing, serum infliximab levels, adverse events |
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Notes | Reported in abstract form only | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not described beyond 'double‐blind' |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Not described |
Selective reporting (reporting bias) | Low risk | All expected outcomes were reported |
Other bias | Unclear risk | Reported in abstract form only |