Masuda 2002

Methods	RCT
Participants	Country: Japan N = 46 ASA: I/II Gender: Female/male 15/5, 15/4 Age: 33±9, 37±14 years. Exclusion ‐ not mentioned Operation: laparotomy (6;4), laparoscopy (7;3), surgery on extremities (5;5), arthroscopy (1;2), surface (1;1), head and neck (0;3) Duration of anaesthesia: 190±45, 191±57
Interventions	Propofol infusion guided by BIS (A‐1050), target BIS value at 40‐60, Cn =20 Propofol guided by standard clinical signs, Cn =19
Outcomes	‐Propofol infusion rate ‐Total amount of propofol used ‐Recovery profiles ‐Patients with undesirable responses
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information
Allocation concealment (selection bias)	Unclear risk	Insufficient information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Low risk	All expected outcomes reported
Other bias	Unclear risk	Insufficient information
Blinding of patients?	Low risk	Patients were anaesthetized
Blinding of anaesthesiologists?	High risk	It was unlikely to blind the anaesthesia provider from the assigned groups
Blinding of outcome assessors?	Unclear risk	Insufficient information