Samarkandi 2004

Methods	RCT
Participants	Country: Saudi Arabia N =40; 20, 20 ASA: not specified Age: mean (SD) 55.3 (10.4), 60.8 (10.2) yr sex: not specified Operation: cardiac revascularization procedure by the off‐pump technique Anaesthesia: intravenous (midazolam, and sufentanil), relaxant (rocuronium), and supplemented sevoflurane Duration: of anaesthesia, mean (SD) min 239.8 (20); 230 (24.5)
Interventions	1. BIS‐guided anaesthetics for maintaining BIS values of 40‐60 2. No BIS monitoring
Outcomes	1. Anaesthetic requirements 2. The need for circulatory support (dosage of phenylephrine) 3. Extubation time 4. Intraoperative recall awareness (Cn, %)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	"Randomization was performed using patient's medical record number, being odds related to group I and evens related to group II"
Allocation concealment (selection bias)	High risk	"Randomization was performed using patient's medical record number, being odds related to group I and evens related to group II"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data reported
Selective reporting (reporting bias)	Low risk	All expected outcomes reported
Other bias	High risk
Blinding of patients?	Low risk	All patients were anaesthetised
Blinding of anaesthesiologists?	High risk	It was not possible to blind the anaesthesiologists
Blinding of outcome assessors?	Low risk	"Postoperatively, patients were visited on the second postoperative day by one of the medical staff about the grouping