Struys 2001

Methods	RCT
Participants	Country: Belgium N = 20 Sex: female Exclusion: neurologic disorders, psychoactive medication including alcohol, body weight above 130% or below 70% of the ideal body weight Operation: gynaecologic laparotomy ‐ASA: I/II ‐Age: 42±8, 46±4 ‐Duration of anaesthesia: 6798±2085; 6896±2018 second
Interventions	Closed‐loop controlled administration of propofol guided by BIS (A‐2000; Aspect Medical Systems Inc,Version 3.4) at value to 50 Manual administration of propofol guided by classical signs of (in)adequate anaesthesia
Outcomes	‐Time to spontaneous breathing ‐Time to eye opening ‐Time to extubation ‐Time to orientation ‐Propofol use (mg/kg/hr)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information about the sequence generation process
Allocation concealment (selection bias)	Unclear risk	Insufficient information about the allocation concealment
Incomplete outcome data (attrition bias) All outcomes	Low risk	"No patients were excluded from analysis."
Selective reporting (reporting bias)	Low risk	All expected outcomes have been reported
Other bias	Unclear risk	Insufficient information about the blinding of the anaesthesiologists
Blinding of patients?	Low risk	All patients were anaesthetized
Blinding of anaesthesiologists?	High risk	It was unlikely to blind the anaesthesia providers to the assigned groups
Blinding of outcome assessors?	Unclear risk	Insufficient information