Comparison 2. Homocysteine‐lowering treatment versus placebo or standard care (Sensitivity analysis).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Myocardial infarction	6	37442	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.94, 1.09]
2.1.1 Trials with low risk of bias	6	37442	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.94, 1.09]
2.2 Stroke	6	37442	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.80, 1.02]
2.2.1 Trials with low risk of bias	6	37442	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.80, 1.02]
2.3 Death from any cause	7	37932	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.95, 1.12]
2.3.1 Trials with low risk of bias	7	37932	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.95, 1.12]