Trial	Myocardial infarction	Stroke	Angina pectoris	Death
B‐PROOF 2015	Not available	Not available	Not available	Not available
BVAIT 2009	Not available	Not available	Not available
CSPPT 2015	Criteria for ischaemic symptoms or corresponding electrocardiographic changes plus evidence of myocardial damage.	Medical records and imaging data	Not measured	Evidence for death included death certificates from hospitals or reports of home visit by investigators
HOPE‐2 2006	2 of the following 3 criteria were met: typical symptoms, increased cardiac‐enzyme levels and diagnostic electrocardiographic changes.	Focal neurologic deficit lasting more than 24 hours. Computed tomography or magnetic resonance imaging was recommended to identify the type of stroke (ischaemic or haemorrhagic). When these tools were not available, the stroke was classified as of uncertain type	Not available	Cardiovascular causes were unexpected deaths presumed to be due to ischaemic cardiovascular disease and occurring within 24 hours after the onset of symptoms without clinical or postmortem evidence of another cause, deaths from myocardial infarction or stroke within 7 days after the event, deaths associated with cardiovascular interventions within 30 days after cardiovascular surgery or within 7 days after percutaneous interventions, and deaths from congestive heart failure, arrhythmia, pulmonary embolism or ruptured aortic aneurysm. Deaths from uncertain causes were presumed to be due to cardiovascular causes	Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined ‐ a consensus document of the joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000;36:959‐69. [Erratum, J Am Coll Cardiol 2001;37:973.]: source not available
Li 2015a	Not measured	Not available	Not measured	Not measured	‐
NORVIT 2006	See supplementary appendix: www.nejm.org	See supplementary appendix: www.nejm.org	See supplementary appendix: www.nejm.org	See supplementary appendix: www.nejm.org	Definitions are too long to summarise in this table
SEARCH 2010	https://www.ctsu.ox.ac.uk/research/research-archive/searchs/search-study-protocol/view Accessed: 7 January 2015	https://www.ctsu.ox.ac.uk/research/research-archive/searchs/search-study-protocol/view Accessed: 7 January 2015	https://www.ctsu.ox.ac.uk/research/research-archive/searchs/search-study-protocol/view Accessed: 7 January 2015	https://www.ctsu.ox.ac.uk/research/research-archive/searchs/search-study-protocol/view Accessed: 7 January 2015	Definitions are too long to summarise in this table
SU.FOL.OM3 2010	Myocardial infarction (ICD‐10 (International Classification of Diseases, 10th revision) codes I21.0–I21.9) was defined on the basis of 2 or more of the criteria: typical chest pain, electrocardiographic changes consistent with myocardial infarction and cardiac enzyme increase	An acute cerebral ischaemic event was defined as an ischaemic cerebrovascular accident based on clinical criteria confirmed by computed tomography or magnetic resonance imaging and a Rankin score 3 at inclusion (ICD‐10 codes I63.0–I63.9)	Acute coronary syndrome without myocardial infarction (ICD‐10 codes I20.0–I20.1) was initially defined by the presence of 3 criteria: typical chest pain, electrocardiographic changes consistent with coronary artery disease without myocardial infarction and evidence of coronary artery disease (myocardial infarction, angina with angiographic evidence of stenosis > 50% in one or more coronary arteries, or angina pectoris corroborated by coronary angiography or exercise testing, or coronary angioplasty or coronary artery bypass graft procedure). Suspected acute coronary syndrome without characteristic electrocardiographic evidence of myocardial infarction provided there was angiographic evidence of coronary artery disease
VISP 2004	New ECG changes including Q waves or marked ST‐T changes plus abnormal cardiac enzymes, cardiac symptoms plus abnormal enzymes or symptoms plus hyperacute ECG changes resolving with thrombolysis	Evidence of sudden onset of focal neurologic deficit lasting at least 24 hours accompanied by an increased NIHSS Score in an area that was previously normal. When the sudden onset of symptoms lasting at least 24 hours was not accompanied by an increased NIHSS Score in an area that was previously normal, then recurrent stroke was diagnosed using cranial CT or MRI evidence of new infarction consistent with the clinical presentation	Not available	Not available
WAFACS 2008	According to World Health Organization criteria	A new neurologic deficit of sudden onset that persisted for more than 24 hours or until death within 24 hours	Not available	Death due to cardiovascular disease was confirmed by examinations of autopsy reports, death certificates, medical records and information obtained from the next kin or other family members. Death from any cause was confirmed by the endpoint committee on the basis of a death certificate
WENBIT 2008	According to the Joint European Society of Cardiology/American College of Cardiology Committee. Eur Heart J. 2000;21:1502‐13	According to Cannon CP, Battler A, Brindis RG, Cox JL, Ellis SG, Every NR, et al. A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee). J Am Coll Cardiol. 2001;38:2114‐30	According to Cannon CP, Battler A, Brindis RG, Cox JL, Ellis SG, Every NR et al. A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee). J Am Coll Cardiol. 2001; 38:2114‐30	If death occurred within 28 days after the onset of an event, the event was classified as fatal