Trial	All hypoglycaemic events	Severe/serious hypoglycaemia	Nocturnal hypoglycaemia	Severe/serious adverse events
Beverly 2013	NI	NI	NI	NI
Davies 2008	NI	NI	NI	NI
Dennick 2015	NI	NI	NI	ND
D'Eramo Melkus 2010	NI	NI	NI	NI
Fisher 2011	IO (< 70 mg/dL or 3.9 mmol/L, based on downloaded meter data)	NI	NI	IO
Fisher 2013	NI	NI	NI	NI
Gabbay 2013	NI	NI	NI	NI
Glasgow 2005	NI	NI	NI	NI
Grillo 2016	NI	NI	NI	NI
Hermanns 2012	NI	NI	NI	NI
Hermanns 2015	NI	NI	NI	NI
Lamers 2011	SO	NI	NI	ND
Lerman 2009	NI	NI	NI	NI
Liu 2015	NI	NI	NI	NI
Pibernik‐Okanovic 2015	NI	NI	NI	ND
Quinn 2011	SO (through quarterly telephone calls to patients)	NI	NI	SO
Rosenbek 2011	NI	NI	NI	NI
Shibayama 2007	NI	NI	NI	NI
Simmons 2015	NI	NI	NI	NI
Skelly 2009	NI	NI	NI	NI
Spencer 2013	NI	NI	NI	NI
Sperl‐Hillen 2013	NI	NI	NI	NI
Sturt 2008	NI	NI	NI	NI
Taylor 2006	NI	NI	NI	ND
Trief 2016	NI	NI	NI	NI
Van der Wulp 2012	NI	NI	NI	NI
Van Dijk‐de Vries 2015	NI	NI	NI	NI
Weinger 2011	ND	SO	ND	ND
Welch 2015	SO (hypoglycaemia was defined in the Diabetes Self‐Care Profile as any "low blood sugars or sweating, nausea, heart pounding, trembling,cold and clammy skin, difficulty concentrating, and irritability" over the past month)	SO	NI	NI
Whittemore 2004	NI	NI	NI	NI
aIn addition to definition of endpoint measurement, description of who measured the outcome (AO: adjudicated outcome measurement; IO: investigator‐assessed outcome measurement;SO: self‐reported outcome measurement) ND: not defined; NI: not investigated