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. 2019 Apr 4;4(7):e124174. doi: 10.1172/jci.insight.124174

Figure 11. Effect of sPRR-His infusion on urine osmolality response to acute arginine vasopressin (AVP) treatment in PRR KO mice.

Figure 11

Urine was emptied by bladder massage and subjected to measurement of osmolality before and after AVP treatment (720 ng/kg body weight). (A and B) Shown is the ratio of the change in urine osmolality in CD PRR–KO mice (n = 6 mice per group) (A) and RT PRR–KO mice (n = 6-7 mice per group) (B). (C) Twenty-four–hour urinary AVP excretion in floxed, CD PRR–KO/vehicle, and CD PRR–KO/sPRR-His mice (n = 6–8 mice per group). (D) Twenty-four–hour urinary AVP excretion in floxed, RT PRR–KO/vehicle,and RT PRR–KO/sPRR-His mice (n = 6 mice per group). Statistical significance was determined by using 1-way ANOVA with the Bonferroni test for multiple comparisons. Data are mean ± SEM. *P < 0.05 vs. control; #P < 0.05 vs. PRR-KO mice alone.