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. 2019 Apr 4;4(7):e124174. doi: 10.1172/jci.insight.124174

Figure 9. Effect of sPRR-His infusion on urine concentrating capability in PRR-KO mice.

Figure 9

CD PRR–KO and RT PRR–KO mice were given sPRR-His infusion at 30 μg/kg/day for 4 and 7 days, respectively. At the end of the experiments, 24-hour urine collections were performed. (A and B) ELISA determination of urinary sPRR excretion (n = 5–8 mice per group). (C) Urine volume in CD PRR–KO mice (n = 5 mice per group). (D) Urine osmolality in CD PRR–KO mice (n = 5 mice per group). (E) Urine volume in RT PRR–KO mice (n = 6 mice per group). (F) Urine osmolality in RT PRR–KO mice (n = 6 mice per group). Statistical significance was determined by using 1-way ANOVA with the Bonferroni test for multiple comparisons. Data are mean ± SEM. *P < 0.05 vs. control; #P < 0.05 vs. PRR KO mice alone.