Lyons 2001.

Methods	RCT, 2 arm trial.
Participants	Setting: 40 women, setting not clear. Inclusion criteria: women with gestational age 40 to 42 weeks, singleton, cephalic presentation, intact membranes, Bishop score < 6, reassuring FHR and < 3 contractions in 10 minutes.
Interventions	Intervention group: 100 mg oral misoprostol, dose repeated every 24 h with maximum of 3 doses. 2 h continual fetal monitoring after each dose. Comparison group: placebo, with same regime and monitoring as the intervention group.
Outcomes	Chorioamnionitis, meconium aspiration, uterine hyperstimulation, mean time to active labour.
Notes	Study reported in brief abstract.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as "randomized".
Allocation concealment (selection bias)	Unclear risk	Placebo controlled, no information on randomisation procedure.
Blinding (performance bias and detection bias) Women	Low risk	Described as double‐blind, placebo controlled study.
Blinding (performance bias and detection bias) Clinical staff	Low risk	Described as double‐blind, placebo controlled study.
Blinding (performance bias and detection bias) Outcome assessor	Unclear risk	Not described.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	All women appeared to have been followed up, but little information.
Selective reporting (reporting bias)	Unclear risk	Study reported in brief abstract; unable to assess this bias domain.
Other bias	Unclear risk	Study reported in brief abstract; unable to assess this bias domain.