Hofmeyr 2011

Trial name or title	The Calcium and Pre‐eclampsia (CAP) Study.
Methods	Double‐blind, placebo‐controlled randomised clinical trial.
Participants	Non‐pregnant women with pre‐eclampsia in their most recent pregnancy.
Interventions	Elemental calcium 500 mg as calcium carbonate daily from enrolment until 20 weeks' gestation, versus placebo.
Outcomes	Primary: pre‐eclampsia. Secondary: pregnancy loss or pre‐eclampsia; severe maternal morbidity and mortality index; conception; pregnancy loss; no conception during study period; pregnancy loss before 24 weeks' gestational age; pregnancy loss/stillbirth; gestational hypertension; gestational proteinuria; severe gestational hypertension; early onset pre‐eclampsia; severe pre‐eclampsia; moderately severe thrombocytopenia; uric acid > reference values for gestational age; renal failure; pulmonary oedema; cerebrovascular accident; liver failure; intensive care unit admission > 24 hour; eclampsia; HELLP syndrome; placental abruption; maternal death; mother’s hospital stay 7 days or more after birth; caesarean section; severe pre‐eclamptic complications index; birthweight < 2500 g; preterm birth; early preterm birth; Apgar score less than 7 at 5 minutes; death or admission to neonatal intensive care unit for 24 hours or more; stillbirth; pregnancy loss, stillbirth or neonatal death before discharge.
Starting date
Contact information	GJ Hofmeyr, Effective Care REsearch Unit, University of the Witwatersrand/Fort Hare; Eastern Cape Department of Health. justhof@gmail.com
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