Comparison 2. High‐dose compared to low‐dose recombinant factor VIIIa (rFVIIIa).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall bleeding rates: number of bleeds per month	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
2 Target joint bleeding rate: number of joint bleeds over 3 months	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3 Number of adverse events	2		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3.1 200 μg/kg vs 100 μg/kg	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 200 μg/kg vs 25 μg/kg	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 100 μg/kg vs 25 μg/kg	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.4 270 μg/kg vs 90 μg/kg	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Number of serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected