Comparison 5. Single‐dose, preoperative MMC‐EMDA versus TURBT alone (long term).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Time to recurrence	1	233	Hazard Ratio (Random, 95% CI)	0.40 [0.28, 0.57]
2 Time to progression	1	233	Hazard Ratio (Random, 95% CI)	0.74 [0.00, 247.93]
3 Serious adverse events	1	233	Risk Ratio (M‐H, Random, 95% CI)	1.74 [0.52, 5.77]
4 Disease‐specific survival	1	233	Hazard Ratio (Random, 95% CI)	1.06 [0.80, 1.40]
5 Time to death	1	233	Hazard Ratio (Random, 95% CI)	1.07 [0.73, 1.57]
6 Minor adverse events	1	233	Risk Ratio (M‐H, Random, 95% CI)	1.68 [1.11, 2.53]