| Date | Event | Description |
|---|---|---|
| 21 August 2017 | New citation required and major changes | New citation due to change in scope, updated methods and new author added. |
| 21 August 2017 | Amended | Protocol amended to meet MECIR standard. Added one additional author (Rupam Gill). Change in scope: in addition to adult patients with hypertension, other non‐hypertensive participants (18 years or older) also included in the updated protocol are postmenopausal women experiencing hot flashes being treated with clonidine and patients using clonidine as a treatment for opioid withdrawal and alcohol addiction. |
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