1 Rate of clinically significant exacerbations |
3 |
751 |
Rate Ratio (Random, 95% CI) |
0.53 [0.44, 0.64] |
1.1 Eosinophilic |
3 |
751 |
Rate Ratio (Random, 95% CI) |
0.53 [0.44, 0.64] |
2 Rate of exacerbations requiring emergency department treatment or admission |
2 |
690 |
Rate Ratio (Random, 95% CI) |
0.52 [0.31, 0.87] |
2.1 Eosinophilic |
2 |
690 |
Rate Ratio (Random, 95% CI) |
0.52 [0.31, 0.87] |
3 Rate of exacerbations requiring admission |
2 |
690 |
Rate Ratio (Random, 95% CI) |
0.61 [0.33, 1.13] |
3.1 Eosinophilic |
2 |
690 |
Rate Ratio (Random, 95% CI) |
0.61 [0.33, 1.13] |
4 People with one or more exacerbations |
1 |
61 |
Risk Ratio (M‐H, Random, 95% CI) |
0.82 [0.61, 1.09] |
4.1 Eosinophilic |
1 |
61 |
Risk Ratio (M‐H, Random, 95% CI) |
0.82 [0.61, 1.09] |
5 Health‐related quality of life (AQLQ) |
2 |
369 |
Mean Difference (Random, 95% CI) |
0.21 [‐0.06, 0.47] |
5.1 Eosinophilic |
2 |
369 |
Mean Difference (Random, 95% CI) |
0.21 [‐0.06, 0.47] |
6 Health‐related quality of life (ACQ) |
2 |
369 |
Mean Difference (Fixed, 95% CI) |
‐0.11 [‐0.32, 0.09] |
6.1 Eosinophilic |
2 |
369 |
Mean Difference (Fixed, 95% CI) |
‐0.11 [‐0.32, 0.09] |
7 Health‐related quality of life (SGRQ) |
1 |
382 |
Mean Difference (Random, 95% CI) |
‐6.4 [‐9.65, ‐3.15] |
7.1 Eosinophilic |
1 |
382 |
Mean Difference (Random, 95% CI) |
‐6.4 [‐9.65, ‐3.15] |
8 Pre‐bronchodilator FEV1 (litres) |
2 |
690 |
Mean Difference (Random, 95% CI) |
0.08 [0.02, 0.15] |
8.1 Eosinophilic |
2 |
690 |
Mean Difference (Random, 95% CI) |
0.08 [0.02, 0.15] |
9 Serious adverse events |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.59 [0.37, 0.94] |
9.1 Eosinophilic |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.59 [0.37, 0.94] |
10 Adverse events leading to discontinuation |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.72 [0.18, 2.92] |
10.1 Eosinophilic |
3 |
751 |
Risk Ratio (M‐H, Random, 95% CI) |
0.72 [0.18, 2.92] |
11 Serum eosinophil level (cells/microlitre) |
1 |
|
Mean Difference (Fixed, 95% CI) |
‐170.0 [‐228.00, ‐110.00] |
11.1 Eosinophilic |
1 |
|
Mean Difference (Fixed, 95% CI) |
‐170.0 [‐228.00, ‐110.00] |