1 Rate of exacerbations requiring systemic corticosteroids |
2 |
953 |
Rate Ratio (Fixed, 95% CI) |
0.43 [0.33, 0.55] |
1.1 Eosinophilic |
2 |
953 |
Rate Ratio (Fixed, 95% CI) |
0.43 [0.33, 0.55] |
2 Rate of exacerbations requiring emergency department treatment or admission |
2 |
953 |
Rate Ratio (Fixed, 95% CI) |
0.67 [0.39, 1.17] |
2.1 Eosinophilic |
2 |
953 |
Rate Ratio (Fixed, 95% CI) |
0.67 [0.39, 1.17] |
3 Health‐related quality of life (AQLQ) |
3 |
1164 |
Mean Difference (Fixed, 95% CI) |
0.28 [0.17, 0.39] |
3.1 Eosinophilic |
3 |
1164 |
Mean Difference (Fixed, 95% CI) |
0.28 [0.17, 0.39] |
4 Health‐related quality of life (ACQ) |
4 |
1652 |
Mean Difference (Fixed, 95% CI) |
‐0.25 [‐0.33, ‐0.17] |
4.1 Eosinophilic |
4 |
1260 |
Mean Difference (Fixed, 95% CI) |
‐0.27 [‐0.36, ‐0.19] |
4.2 Non‐eosinophilic |
1 |
392 |
Mean Difference (Fixed, 95% CI) |
‐0.12 [‐0.33, 0.09] |
5 Pre‐bronchodilator FEV1 (litres) |
4 |
1652 |
Mean Difference (Fixed, 95% CI) |
0.11 [0.07, 0.15] |
5.1 Eosinophilic |
4 |
1260 |
Mean Difference (Fixed, 95% CI) |
0.12 [0.08, 0.16] |
5.2 Non‐eosinophilic |
1 |
392 |
Mean Difference (Fixed, 95% CI) |
0.03 [‐0.07, 0.14] |
6 Serious adverse events |
4 |
1656 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.56, 1.12] |
6.1 Eosinophilic |
3 |
1160 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.51, 1.22] |
6.2 Eosinophil status unknown |
1 |
496 |
Risk Ratio (M‐H, Random, 95% CI) |
0.98 [0.34, 2.88] |
7 Adverse events leading to discontinuation |
4 |
1659 |
Risk Ratio (M‐H, Random, 95% CI) |
0.66 [0.43, 1.02] |
7.1 Eosinophilic |
3 |
1163 |
Risk Ratio (M‐H, Random, 95% CI) |
0.67 [0.37, 1.20] |
7.2 Eosinophil status unknown |
1 |
496 |
Risk Ratio (M‐H, Random, 95% CI) |
0.66 [0.35, 1.23] |
8 Serum eosinophil level (cells/microlitre) |
4 |
1656 |
Mean Difference (Fixed, 95% CI) |
‐476.83 [‐499.32, ‐454.34] |
8.1 Eosinophilic |
4 |
1656 |
Mean Difference (Fixed, 95% CI) |
‐476.83 [‐499.32, ‐454.34] |