1 Rate of exacerbations requiring systemic corticosteroids |
3 |
2456 |
Rate Ratio (Fixed, 95% CI) |
0.62 [0.55, 0.70] |
1.1 Eosinophilic |
3 |
1698 |
Rate Ratio (Fixed, 95% CI) |
0.59 [0.51, 0.68] |
1.2 Non‐eosinophilic |
2 |
758 |
Rate Ratio (Fixed, 95% CI) |
0.69 [0.56, 0.85] |
2 Rate of exacerbations requiring emergency department treatment or admission |
2 |
1537 |
Rate Ratio (Fixed, 95% CI) |
0.68 [0.47, 0.98] |
2.1 Eosinophilic |
2 |
1537 |
Rate Ratio (Fixed, 95% CI) |
0.68 [0.47, 0.98] |
3 Health‐related quality of life (AQLQ mean difference) |
3 |
1541 |
Mean Difference (Fixed, 95% CI) |
0.23 [0.11, 0.35] |
3.1 Eosinophilic |
3 |
1541 |
Mean Difference (Fixed, 95% CI) |
0.23 [0.11, 0.35] |
4 Health‐related quality of life (ACQ mean difference) |
3 |
2359 |
Mean Difference (Fixed, 95% CI) |
‐0.20 [‐0.29, ‐0.11] |
4.1 Eosinophilic |
3 |
1604 |
Mean Difference (Fixed, 95% CI) |
‐0.23 [‐0.34, ‐0.12] |
4.2 Non‐eosinophilic |
2 |
755 |
Mean Difference (Fixed, 95% CI) |
‐0.14 [‐0.30, 0.02] |
5 Pre‐bronchodilator FEV1 (litres) |
3 |
2355 |
Mean Difference (Fixed, 95% CI) |
0.10 [0.05, 0.14] |
5.1 Eosinophilic |
3 |
1617 |
Mean Difference (Fixed, 95% CI) |
0.13 [0.08, 0.19] |
5.2 Non‐eosinophilic |
2 |
738 |
Mean Difference (Fixed, 95% CI) |
0.03 [‐0.03, 0.10] |
6 Serious adverse events |
4 |
2648 |
Risk Ratio (M‐H, Random, 95% CI) |
0.81 [0.66, 1.01] |
6.1 Eosinophilic |
2 |
1537 |
Risk Ratio (M‐H, Random, 95% CI) |
0.80 [0.60, 1.06] |
6.2 Non‐eosinophilic |
2 |
758 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.57, 1.27] |
6.3 Eosinophil status unknown |
2 |
353 |
Risk Ratio (M‐H, Random, 95% CI) |
0.75 [0.37, 1.51] |
7 Adverse events leading to discontinuation |
3 |
2597 |
Risk Ratio (M‐H, Random, 95% CI) |
2.15 [1.02, 4.57] |
7.1 Eosinophilic |
2 |
1537 |
Risk Ratio (M‐H, Random, 95% CI) |
2.70 [0.86, 8.49] |
7.2 Non‐eosinophilic |
2 |
758 |
Risk Ratio (M‐H, Random, 95% CI) |
1.81 [0.54, 6.05] |
7.3 Eosinophil status unknown |
1 |
302 |
Risk Ratio (M‐H, Random, 95% CI) |
1.82 [0.31, 10.69] |
8 Serum eosinophil level (% change from baseline) |
2 |
2295 |
Mean Difference (Fixed, 95% CI) |
‐104.74 [‐116.12, ‐93.35] |
8.1 Eosinophilic |
2 |
1537 |
Mean Difference (Fixed, 95% CI) |
‐101.74 [‐113.27, ‐90.21] |
8.2 Non‐eosinophilic |
2 |
758 |
Mean Difference (Fixed, 95% CI) |
‐216.81 [‐287.35, ‐146.28] |