2. Effect of definition of test positivity.

Cut‐off	Analysis	Studies (n)	Sensitivity (95% CI)	Specificity (95% CI)
0.5		27	0.78 (0.70 to 0.85)	0.85 (0.78 to 0.91)
	Single sample	13	0.79 (0.69 to 0.88)	0.80 (0.71 to 0.90)
	Subsequent samples	14	0.77 (0.67 to 0.87)	0.88 (0.81 to 0.94)
1.0		8	0.71 (0.63 to 0.78)	0.90 (0.86 to 0.93)
	Single sample	4	0.72 (0.62 to 0.82)	0.87 (0.81 to 0.93)
	Subsequent samples	4	0.70 (0.59 to 0.80)	0.92 (0.88 to 0.96)
1.5		15	0.63 (0.49 to 0.77)	0.93 (0.89 to 0.97)
	Single sample	8	0.64 (0.48 to 0.80)	0.92 (0.86 to 0.97)
	Subsequent samples	7	0.61 (0.45 to 0.78)	0.95 (0.91 to 0.98)

CI: confidence interval