3. Effect definition of 'diseased' patients.

Cut‐off value and analysis	Proven and probable versus possible and no IA			Proven versus probable, possible and no IA			Proven, probable and possible versus no IA
	n	Sensitivity (95% CI)	Specificity (95% CI)	n	Sensitivity (95% CI)	Specificity (95% CI)	n	Sensitivity (95% CI)	Specificity (95% CI)
0.5 ODI	27	0.78 (0.70 to 0.85)	0.85 (0.78 to 0.91)	18	0.89 (0.79 to 0.99)	0.72 (0.62 to 0.82)	19	0.55 (0.41 to 0.69)	0.87 (0.80 to 0.94)
1.0 ODI	8	0.71 (0.63 to 0.78)	0.90 (0.86 to 0.93)	8	0.79 (0.70 to 0.89)	0.83 (0.78 to 0.88)	8	0.54 (0.44 to 0.65)	0.93 (0.90 to 0.96)
1.5 ODI	15	0.63 (0.49 to 0.77)	0.93 (0.89 to 0.97)	14	0.65 (0.48 to 0.83)	0.91 (0.86 to 0.96)	14	0.54 (0.36 to 0.71)	0.97 (0.94 to 0.99)

CI: confidence interval; IA: invasive aspergillosis; ODI: optical density index