Adam 2004.

Study characteristics
Patient sampling	Prospective; consecutive enrollment of patients not reported Platelia ODI between 1.0 and 1.5 were excluded
Patient characteristics and setting	225 participants Age ranged from 16 to 74 years No information about gender France Adults with haematological malignancies who were likely to be severely neutropenic. Inpatients, monitoring clinical course. Representative spectrum? Unclear: although galactomannan antigenaemia is monitored weekly in those patients with haematological malignancies who are likely to experience severe neutropenia, it is not clear whether the patients were enrolled consecutively
Index tests	Platelia: galactomannan antigenaemia is monitored weekly; first positive result is regarded positive. Cut‐off 1.5 ODI
Target condition and reference standard(s)	Invasive aspergillosis, defined according to EORTC criteria, reference Ascioglu 2002 Incorporation avoided? Unclear: not reported Acceptable reference standard? Yes: a diagnosis of invasive aspergillosis was classified as proven, probable or possible, according to criteria established by the EORTC/MSG (Ascioglu 2002)
Flow and timing	Not reported Partial verification avoided? Yes: all patients were classified according to the reference criteria Withdrawals explained? Yes: see above Uninterpretable results reported? No: Platelia ODI between 1.0 and 1.5 were excluded
Comparative
No patients per category	0 proven; 2 probable; 5 possible; 218 non‐IA
Notes	Sponsoring? Nothing reported on financial resources
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	No
		High	Unclear
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low