Bialek 2002.
| Study characteristics | |||
| Patient sampling | Study design not clear | ||
| Patient characteristics and setting | 17 participants
Age ranged from 1 month to 9 years; 59% males France or Germany Children undergoing bone marrow transplantation (BMT), no other details reported Paediatric bone marrow recipients; other details not reported |
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| Index tests | Platelia: screening (but not reported how often), single sample positive is positive; < 1.0 is negative and > 1.5 is positive | ||
| Target condition and reference standard(s) | Invasive aspergillosis, according to EORTC criteria, EORTC website cited They excluded the antigen detection as a microbiological criterion in the EORTC criteria |
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| Flow and timing | None very clearly reported: not clearly reported whether all patients who underwent the Platelia test also underwent the reference standard No withdrawals reported Uninterpretable results not clearly reported: below 1.0 ODI a sample is negative, above 1.5 ODI a sample is positive, but they do not describe how samples between 1.0 and 1.5 ODI are handled |
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| Comparative | |||
| No patients per category | 0 proven, 1 probable, 2 possible, 14 non‐IA | ||
| Notes | Research fund and university fund reported | ||
| Methodological quality | |||
| Item | Authors' judgement | Risk of bias | Applicability concerns |
| DOMAIN 1: Patient Selection | |||
| Was a consecutive or random sample of patients enrolled? | Unclear | ||
| Was a case‐control design avoided? | Yes | ||
| Did the study avoid inappropriate exclusions? | Unclear | ||
| Unclear | Unclear | ||
| DOMAIN 2: Index Test All tests | |||
| Were the index test results interpreted without knowledge of the results of the reference standard? | Yes | ||
| If a threshold was used, was it pre‐specified? | Yes | ||
| Low | Low | ||
| DOMAIN 3: Reference Standard | |||
| Is the reference standards likely to correctly classify the target condition? | Yes | ||
| Were the reference standard results interpreted without knowledge of the results of the index tests? | Yes | ||
| Low | Low | ||
| DOMAIN 4: Flow and Timing | |||
| Was there an appropriate interval between index test and reference standard? | Yes | ||
| Did all patients receive the same reference standard? | Yes | ||
| Were all patients included in the analysis? | Unclear | ||
| Unclear | |||