Doermann 2002.

Study characteristics
Patient sampling	Study design not clear
Patient characteristics and setting	423 adult participants Age of cases ranged from 16 to 70 years; no information about gender Haematology department France Inpatients, no further information provided
Index tests	Platelia: no further details reported Sera were tested twice a week in patients at risk 2 consecutive samples is positive, the rest are negative Cut‐off = 1.5 ng/ml
Target condition and reference standard(s)	Invasive aspergillosis, according to EORTC‐like criteria Antigenaemia reported as criterion in one of the definitions for disease classifications Acceptable reference standard? Yes EORTC‐like criteria; definitions of separate groups reported completely
Flow and timing	All patients were evaluated according to the same criteria, but not clear whether there were withdrawals or uninterpretable results
Comparative
No patients per category	3 proven, 9 probable, 6 possible, 405 non‐IA
Notes	Language: French Sponsoring precluded? Unclear: not reported
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Unclear
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Unclear	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Unclear
Were the reference standard results interpreted without knowledge of the results of the index tests?	No
		High	Unclear
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Unclear
		Unclear