Kallel 2003.

Study characteristics
Patient sampling	Prospective; series of patients with same risk profile Not reported whether enrollment was consecutive
Patient characteristics and setting	74 participants Age ranged from 8 to 47 years No information about gender Tunisia Children and adults who were neutropenic; predominantly allograft patients Inpatients, monitoring clinical course Representative spectrum? Yes: children and adults that were neutropenic; predominantly allograft patients Prospective, consecutive patient series
Index tests	Platelia. Sera were monitored weekly on Mondays and Tuesdays. Both days positive = positive. All other results = negative. Cut‐off 1.5 ODI
Target condition and reference standard(s)	Invasive aspergillosis, as defined by EORTC criteria (Ascioglu 2002) Incorporation avoided? No: a positive galactomannan test was one of the requirements for probable IA
Flow and timing	Not reported Partial verification avoided? Yes: all patients were classified according to reference criteria Withdrawals explained? No Uninterpretable results reported? No
Comparative
No patients per category	1 proven, 4 probable, 2 possible, 67 no
Notes	Sponsoring precluded? Unclear: nothing reported about financial support French
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	No
		High	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Unclear
		Unclear